| Ronald W. Haughton Papers | 1946-1969 | | LP000049 |
| Samuel Halperin Papers | 1959 | | WSP000406 |
| David Herreshoff Papers | 1959-1971 | | UP000692 |
| Wayne State University Health and Physical Education Division Records | 1940-1960 | | WSR000198 |
| Wayne State University Health Service Annual Reports | 1936-1968 | | WSR000436 |
| Grace Hill Papers | circa 1930s | | WSP000009 |
| W. Sprague Holden Papers | 1900-1969 | | WSP000366 |
| Wayne State University Information Center Records | 1939-1975, bulk 1953-1975 | | WSR000063 |
| Wayne State University Information Services Records | 1940-1968 | | WSR000169 |
| Wayne State University Institute of Labor and Industrial Relations Area Manpower Institute for Development of Staff Records | 1967-1974 | | WSR000334 |
| Alpheus F. Jennings Papers | 1914 | | WSP000397 |
| Mark L. Kahn Papers | 1952-1970 | | LP000605 |
| J.B. Kennedy Papers | 1890-1895 | | WSP000133 |
| Kurt Keydel Papers | 1946-1967 | | WSP000226 |
| Wayne State University Kresge-Hooker Science Library Associates Records | 1881-1971, bulk 1943-1960 | | WSR000194 |
| Aaron A. Kutnick Papers | 1937-1938 | | WSP000187 |
| Florence E. Kuhn Papers | 1917-1918 | | WSP000097 |
| Edward H. Lauppe Papers | circa 1877 | | WSP000282 |
| Lewis B. Larkin Papers | 1922-1970 | | WSP000122 |
| Roland T. Lakey Records | 1905-1974 | | WSP000357 |
| Wayne State University Law School Newsletters | 1952-2009 | | WSR002163 |
| Wayne State University Law School Student Directories | 1956-1992 | | WSR002159 |
| C. Henri Leonard, M.D. Papers | 1879-1907 | | WSP000398 |
| Madeleine M. Leininger Papers | 1953-1995, bulk 1961-1995 | | WSP000725 |
| Samuel M. Levin Papers | 1871-1975 | | WSP000059 |
| Willard R. Lenz Papers | 1927-1932 | | WSP000051 |
| Paul Lutzeier Records | 1922-1967 | | WSP000010 |
| David Mackenzie Papers | 1882-1926 | | WSP000480 |
| Donald C. Marsh Papers | 1937-1976 | | WSP000019 |
| Donald Martyn Papers | 1906-1908 | | WSP000052 |
| Mackenzie Union Financial Records | 1933-1938 | | WSR000001 |
| Edward McFarland Papers | 1926-1950 | | WSP000066 |
| Theodore McGraw, Jr. Diary | 1898 | | WSP000050 |
| Wilson McTeer Records | 1938-1970 | | WSP000026 |
| Wayne State University Medical Articles and Reprints | 1859,1877-1966, bulk 1900-1940 | | WSR000000_MAR |
| Wayne University Medical Library Records | 1901-1949 | | WSR000105 |
| Wayne University Medical Science Center | 1940-1952, bulk 1942-1946 | | WSR000510 |
| Michigan Library Consortium Records | 1973 | | WSR000315 |
| Raymond Miller Papers | 1945 | | WSP000350 |
| Theodore Miles Papers | 1942-1945 | | |
| Wayne State University Miles Modern Poetry Committee Records | 1946-1974 | | WSR000150 |
| Robert C. Moehlig M.D. Papers | 1919-1960 | | WSP000145 |
| Wayne State University Monteith College Records | 1958-1972 | | WSR000453 |
| Wayne State University Office of Student Organizations Student Organization Files | 1936–1975, bulk 1960-1972 | | WSR000205 |
| Wayne State University Office of the Bursar Records | 1938-1976, bulk 1959-1966 | | WSR000424 |
| Wayne State University Office of the President Clarence B. Hilberry Records | 1928, 1930-1966 | | WSR000001 |
| Wayne State University Office of the President David D. Henry Records | 1933-1959 | | WSR00001H |
| Wayne State University Office of the President Warren E. Bow Records | 1942-1945 | | WSR00001B |
| Wayne State University Office of the President William Rea Keast Records | 1965-1971 | | WSR001883 |
| Delos L. Parker Papers | 1898 | | WSP000399 |
| Everett R. Phelps Papers | 1948-1961 | | WSP000175 |
| Phi Lambda Theta Records | 1939-1947 | | WSR000010 |
| Vergil Phelps Papers | 1864-1972, bulk 1924-1967 | | WSP000403 |
| Louise Potter Papers | 1920-1924 | | WSP000275 |
| Preservation Wayne Records | 1975-2010, bulk 1977-2008 | | WSR000604 |
| Wayne State University President's Reports | 1944-1954, 1998-2007 | | WSR002145 |
| Wayne State University Press Editorial Board Minutes and General Information Reports | 1941-1980 | | WSR002143 |
| Wayne State University Quarter System Ad Hoc Committee Records | 1957 | | WSR000286 |
| Eloise Ramsey Papers | 1910-1958 | | WSP000467 |
| Haviland F. Reves Records | 1923-1971 | | WSP000245 |
| Sarah Schilling Schooten Papers | 1921 | | WSP000182 |
| Wayne State University School of Medicine Student Directories | 1970-1975 | | WSR002161 |
| Wayne State University School of Occupational Health Office of the Dean Raymond Hussey Records | 1945-1949 | | WSR000067 |
| Douglas R. Sherman Papers | circa 1965 | | WSP000213 |
| E. Ray Skinner Papers | 1932-1957 | | WSP000162 |
| Charles Spain Papers | 1919-1944 | | WSP000016 |
| Wayne State University Staff Association Records | 1956-1969 | | LR000282 |
| Wayne State University Student Activities Counseling Inactive Student Organization Files | 1941-1991, bulk 1970-1979 | | WSR000205 |
| Wayne State University Student Handbooks | 1921-2000 | | WSR002157 |
| William J. Stapleton, Jr. Papers | 1902-1961 | | WSP000030 |
| William R. Stocking, Jr. Papers | 1901-1956 | | WSP000006 |
| Wayne University Theaters Records | 1910, 1925-1953 | | WSR000136 |
| Frank Tompkins Papers | undated | | WSP000153 |
| William M. Trap Papers | 1937-1950 | | WSP000348 |
| Dan Trivich Papers | 1954-1980 | | WSP000569 |
| Arthur C. Turgeon Papers | 1931 | | WSP000188 |
| Wayne State University University Relations Division Records | 1936-1977 | | WSR000005 |
| Wayne State University University Services and Development Vice President William E. Stirton Records | 1935-1956, bulk 1952-1955 | | WSR000576 |
| Alexander J. Walt Papers | 1962-1996 | | WSP000732 |
| Frank S. Walker Papers | 1896, 1905 | | WSP000111 |
| Wayne State University Wayne University Club Records | 1937-1971 | | WSR000132 |
| WDET Program Guides and Reports | 1951-2002 | | WSR002162 |
| Alfred H. Whittaker Papers | 1940-1954 | | UP000757 |
| Eleanor Wolf Papers | 1936-1939 | | WSP000239 |
| Wayne State University Women's Resource Center Records | 1972-2003, bulk 1976-1998 | | WSR001819 |
| Wayne State University Yearbooks | 1900-2005 | | WSR002149 |
| Jerry and Mildred Wurf Papers | 1936-1982, bulk 1952-1981 | | LP001132 |
| Captain J. H. Wylie Papers | 1942-1970, bulk 1959-1964 | | LP000678 |
| Cornelius J. Yaklin Papers | 1937 | | LP000505 |
| Minoru Yamasaki Papers | 1915-2001, bulk 1955-1980 | | UP002108 |
| Winthrop Yinger Papers | 1959-1970 | | LP001020 |
| Coleman Young Papers | 1964-1993, bulk 1993 | | UP000449 |
| Holgate Young Papers | 1948-1975, bulk 1955-1975 | | LP000546 |
| Young Woman's Home Association Records | 1877-2003 | | UR001923 |
| John Zaremba Papers | 1935-1961 | | LP000013 |
| John Zieger Papers | 1942-1980 | | LP000843 |
| Richard Zweiback Papers | 1964-1966 | | LP000268 |